Cancer morbidity in rheumatoid arthritis: role of estrogen metabolites

Khan, Wahid Ali and Khan, Mohd Wajid Ali Khan 2013. Cancer morbidity in rheumatoid arthritis: role of estrogen metabolites. BioMed Research International 2013 , 748178. 10.1155/2013/748178

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Abstract

Estrogen metabolites have been implicated in rheumatoid arthritis (RA) and cancer, although the mechanism remains unestablished. Some estrogen metabolites, which are used for the assessment of cancer risk, play an important role in RA. The pathways by which malignancies associated with RA remain elusive. Possible mechanism involves enzymatic or nonenzymatic oxidation of estrogen into catecholestrogen metabolites through semiquinone and quinone redox cycle to produce free radicals that can cause DNA modifications. Modifications of DNA alter its immunogenicity and trigger various immune responses leading to elevated levels of cancer and RA antibodies. However, the role of different estrogen metabolites as a mediator of immune response cannot be ruled out in various immune-related diseases.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Hindawi Publishing Corporation
ISSN:	2314-6133
Date of First Compliant Deposit:	11 April 2018
Date of Acceptance:	17 August 2013
Last Modified:	15 May 2023 23:47
URI:	https://orca.cardiff.ac.uk/id/eprint/110016

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