Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Heavy metal resistance genes are associated with blaNDM-1 and blaCTX-M-15-Enterobacteriaceae

Yang, Qiu E, Agouri, Siham Rajab, Tyrrell, Jonathan Mark ORCID: and Walsh, Timothy Rutland ORCID: 2018. Heavy metal resistance genes are associated with blaNDM-1 and blaCTX-M-15-Enterobacteriaceae. Antimicrobial Agents and Chemotherapy 62 (5) , e02642-17. 10.1128/AAC.02642-17

[thumbnail of Yang QE et al.pdf]
PDF - Published Version
Available under License Creative Commons Attribution No Derivatives.

Download (3MB) | Preview


The occurrence of heavy metal resistance genes in multiresistant Enterobacteriaceae possessing blaNDM-1 or blaCTX-M-15 genes was examined by PCR and pulsed-field gel electrophoresis with S1 nuclease. Compared with clinical susceptible isolates (10.0% to 30.0%), the pcoA, merA, silC, and arsA genes occurred with higher frequencies in blaNDM-1-positive (48.8% to 71.8%) and blaCTX-M-15-positive (19.4% to 52.8%) isolates, and they were mostly located on plasmids. Given the high association of metal resistance genes with multidrug-resistant Enterobacteriaceae, increased vigilance needs to be taken with the use of heavy metals in hospitals and the environment.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: American Society for Microbiology
ISSN: 0066-4804
Date of First Compliant Deposit: 22 March 2018
Date of Acceptance: 5 March 2018
Last Modified: 07 Feb 2023 16:28

Citation Data

Cited 30 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics