Neller, M. A., Burrows, J. M., Rist, M. J., Miles, J. J. and Burrows, S. R. 2013. High frequency of herpesvirus-specific clonotypes in the human T cell repertoire can remain stable over decades with minimal turnover. Journal of Virology 87 (1) , pp. 697-700. 10.1128/JVI.02180-12 |
Official URL: http://dx.doi.org/10.1128/JVI.02180-12
Abstract
High-throughput T cell receptor sequencing on sequentially banked blood samples from healthy individuals has shown that high-frequency clonotypes can remain relatively stable for up to 18 years, with minimal inflation, deflation, or turnover. These populations included T cell expansions specific for Epstein-Barr virus. Thus, in spite of exposure to a barrage of microorganisms over the course of life, the dominant clonotypes in the mature peripheral T cell repertoire can alter surprisingly little.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine |
Publisher: | American Society for Microbiology |
ISSN: | 0022-538X |
Date of Acceptance: | 13 October 2012 |
Last Modified: | 10 Jun 2023 01:07 |
URI: | https://orca.cardiff.ac.uk/id/eprint/110396 |
Citation Data
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