Individual MHCI-restricted T-Cell receptors are characterized by a unique peptide recognition signature

Wooldridge, Linda 2013. Individual MHCI-restricted T-Cell receptors are characterized by a unique peptide recognition signature. Frontiers in Immunology 4 , 199. 10.3389/fimmu.2013.00199

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Abstract

Effective immunity requires that a limited TCR repertoire is able to recognize a vast number of foreign peptide-MHCI (peptide-major histocompatibility complex class I) molecules. This challenge is overcome by the ability of individual TCRs to recognize large numbers of peptides. Recently, it was demonstrated that MHCI-restricted TCRs can recognize up to 106 peptides of a defined length. Astonishingly, this remarkable level of promiscuity does not extend to peptides of different lengths, a fundamental observation that has broad implications for CD8+ T-cell immunity. In particular, the findings suggest that effective immunity can only be achieved by mobilization of “length-matched” CD8+ T-cell clonotypes. Overall, recent findings suggest that every TCR is specific for a unique set of peptides, which can be described as a unique “peptide recognition signature” (PRS) and consists of three components: (1) peptide length preference, (2) number of peptides recognized; and, (3) sequence identity (e.g., self versus pathogen derived). In future, the ability to de-convolute peptide recognition signatures across the normal and pathogenic repertoire will be essential for understanding the system requirements for effective CD8+ T-cell immunity and elucidating mechanisms which underlie CD8+ T-cell mediated disease.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	MHCI-peptide length;T-cell crossreactivity; vaccination; autoimmunity; alloreactivity
Publisher:	Frontiers Media
ISSN:	1664-3224
Date of First Compliant Deposit:	9 October 2018
Date of Acceptance:	23 July 2013
Last Modified:	26 May 2023 07:00
URI:	https://orca.cardiff.ac.uk/id/eprint/110427

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