Niclosamide, a drug with many (re)purposes

Kadri, Hachemi, Lambourne, Olivia A and Mehellou, Youcef ORCID: https://orcid.org/0000-0001-5720-8513 2018. Niclosamide, a drug with many (re)purposes. ChemMedChem 13 (11) , pp. 1088-1091. 10.1002/cmdc.201800100

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Abstract

Niclosamide is an anthelmintic drug that has mainly been used for over 50 years to treat tapeworm infections. However, with the increase in drug repurposing initiatives, niclosamide has emerged as a true hit in many screens against various diseases. Indeed, from being an anthelmintic drug, it has now shown potential in treating Parkinson's disease, diabetes, viral and microbial infections as well as various cancers. Such diverse pharmacological activities are a result of niclosamide's ability to uncouple mitochondrial phosphorylation and modulate a selection of signaling pathways, such as Wnt/β‐catenin, mTOR and JAK/STAT3, which are implicated many diseases. In this highlight, we will discuss the plethora of diseases that niclosamide has shown promise in treating.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Publisher:	Wiley-VCH Verlag
ISSN:	1860-7179
Date of First Compliant Deposit:	10 April 2018
Date of Acceptance:	29 March 2018
Last Modified:	17 Nov 2024 10:30
URI:	https://orca.cardiff.ac.uk/id/eprint/110614

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