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A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway

Mazein, Alexander, Watterson, Steven, Hsieh, Wei-Yuan, Griffiths, William J. and Ghazal, Peter ORCID: 2013. A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway. Biochemical Pharmacology 86 (1) , pp. 56-66. 10.1016/j.bcp.2013.03.021

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Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Publisher: Elsevier
ISSN: 0006-2952
Last Modified: 23 Oct 2022 14:02

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