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Automated operant assessments of Huntington's Disease mouse models

Yhnell, Emma and Heuer, Andreas 2018. Automated operant assessments of Huntington's Disease mouse models. In: Precious, S., Rosser, A. and Dunnett, S. eds. Huntington’s Disease, Vol. 1780. Methods in Molecular Biology, Springer, pp. 143-162. (10.1007/978-1-4939-7825-0_8)

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Huntington’s disease (HD) presents clinically with a triad of motor, cognitive, and psychiatric symptoms. Cognitive symptoms often occur early within the disease progression, prior to the onset of motor symptoms, and they are significantly burdensome to people who are affected by HD. In order to determine the suitability of mouse models of HD in recapitulating the human condition, these models must be behaviorally tested and characterized. Operant behavioral testing offers an automated and objective method of behaviorally profiling motor, cognitive, and psychiatric dysfunction in HD mice. Furthermore, operant testing can also be employed to determine any behavioral changes observed after any associated interventions or experimental therapeutics. We here present an overview of the most commonly used operant behavioral tests to dissociate motor, cognitive, and psychiatric aspects of mouse models of HD.

Item Type: Book Section
Date Type: Published Online
Status: Published
Schools: Medicine
Publisher: Springer
ISBN: 9781493978243
ISSN: 1064-3745
Date of First Compliant Deposit: 20 June 2018
Date of Acceptance: 25 May 2018
Last Modified: 06 Mar 2020 15:08

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