Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal-organic frameworks

Burrows, Andrew D., Jurcic, Monika, Keenan, Luke L., Lane, Rebecca A., Mahon, Mary F., Warren, Mark R., Nowell, Harriott, Paradowski, Michael and Spencer, John 2013. Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal-organic frameworks. Chemical Communications 49 (96) , pp. 11260-11262. 10.1039/c3cc45689g

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Abstract

A series of new zinc-based metal–organic framework materials has been prepared in which deferiprone is incorporated as a chelating ligand on infinite or tri-zinc secondary building units following deprotonation. Deferiprone is immediately released from the MOFs on treatments with 1 N hydrochloric acid or buffer, but slow release is observed in ethanoic acid.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Royal Society of Chemistry
ISSN:	1359-7345
Last Modified:	08 Feb 2024 02:05
URI:	https://orca.cardiff.ac.uk/id/eprint/112614

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