A cyclosporine derivative is a substrate of the oligopeptide transporter PepT1

Foley, David W. ORCID: https://orcid.org/0000-0001-8449-4754, Bermudez, Isabel, Bailey, Patrick D. and Meredith, David 2016. A cyclosporine derivative is a substrate of the oligopeptide transporter PepT1. MedChemComm 7 (5) , pp. 999-1002. 10.1039/C5MD00575B

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Abstract

The mammalian proton-coupled oligopeptide transporter PepT1 is recognised as an important route of oral drug delivery. Peptide-based compounds offer great potential as drugs but their application is limited by poor membrane permeability, amongst other challenges. Using cyclosporin A as a proof-of-concept, we demonstrate for the first time that peptidic molecules over 1000 Da in size can be targeted towards and transported by PepT1.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Schools > Biosciences
Publisher:	Royal Society of Chemistry
ISSN:	2040-2503
Date of Acceptance:	12 March 2016
Last Modified:	23 Oct 2022 14:13
URI:	https://orca.cardiff.ac.uk/id/eprint/113074

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