The ticking CLOCK of HSV-2 pathology

Bayliss, Rebecca J. ORCID: https://orcid.org/0000-0002-3324-957X and Piguet, Vincent 2018. The ticking CLOCK of HSV-2 pathology. Journal of Investigative Dermatology 138 (1) , pp. 17-19. 10.1016/j.jid.2017.08.028

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Abstract

Herpes simplex virus type 2 (HSV-2) is the causative agent of genital herpes. Matsuzawa et al have demonstrated that, in a mouse model, HSV-2 pathology is influenced by the time infection occurs. Increased expression of the HSV-2 receptor Nectin-1 under the control of CLOCK coincided with an increase in viral titer suggesting that HSV-2 infection is regulated by the host circadian clock.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Nature Publishing Group
ISSN:	0022-202X
Date of First Compliant Deposit:	16 July 2018
Date of Acceptance:	20 November 2017
Last Modified:	05 Dec 2024 23:45
URI:	https://orca.cardiff.ac.uk/id/eprint/113193

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