Crunelli, Vincenzo  ORCID: https://orcid.org/0000-0001-7154-9752, Gould, Timothy M. and Parri, Harri Rheinallt
2001.
Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation.
Nature Neuroscience
, pp. 803-812.
10.1038/90507
|
Abstract
Astrocytes respond to chemical, electrical and mechanical stimuli with transient increases in intracellular calcium concentration ([Ca2+]i). We now show that astrocytes in situ display intrinsic [Ca2+]i oscillations that are not driven by neuronal activity. These spontaneous astrocytic oscillations can propagate as waves to neighboring astrocytes and trigger slowly decaying NMDA receptor-mediated inward currents in neurons located along the wave path. These findings show that astrocytes in situ can act as a primary source for generating neuronal activity in the mammalian central nervous system.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Biosciences Research Institutes & Centres > Neuroscience and Mental Health Research Institute (NMHII) |
| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| ISSN: | 1097-6256 |
| Last Modified: | 01 Dec 2022 10:04 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/1132 |
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