Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation

Crunelli, Vincenzo ORCID: https://orcid.org/0000-0001-7154-9752, Gould, Timothy M. and Parri, Harri Rheinallt 2001. Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation. Nature Neuroscience , pp. 803-812. 10.1038/90507

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Abstract

Astrocytes respond to chemical, electrical and mechanical stimuli with transient increases in intracellular calcium concentration ([Ca2+]i). We now show that astrocytes in situ display intrinsic [Ca2+]i oscillations that are not driven by neuronal activity. These spontaneous astrocytic oscillations can propagate as waves to neighboring astrocytes and trigger slowly decaying NMDA receptor-mediated inward currents in neurons located along the wave path. These findings show that astrocytes in situ can act as a primary source for generating neuronal activity in the mammalian central nervous system.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
ISSN:	1097-6256
Last Modified:	01 Dec 2022 10:04
URI:	https://orca.cardiff.ac.uk/id/eprint/1132

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