Hippocampal-anterior thalamic pathways for memory: uncovering a network of direct and indirect actions

Aggleton, John Patrick ORCID: https://orcid.org/0000-0002-5573-1308, O'Mara, Shane M., Vann, Seralynne Denise ORCID: https://orcid.org/0000-0002-6709-8773, Wright, Nicholas Fraser, Tsanov, Marian and Erichsen, Jonathan Thor ORCID: https://orcid.org/0000-0003-1545-9853 2010. Hippocampal-anterior thalamic pathways for memory: uncovering a network of direct and indirect actions. European Journal of Neuroscience 31 (12) , pp. 2292-2307. 10.1111/j.1460-9568.2010.07251.x

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Abstract

This review charts recent advances from a variety of disciplines that create a new perspective on why the multiple hippocampal–anterior thalamic interconnections are together vital for human episodic memory and rodent event memory. Evidence has emerged for the existence of a series of parallel temporal–diencephalic pathways that function in a reciprocal manner, both directly and indirectly, between the hippocampal formation and the anterior thalamic nuclei. These extended pathways also involve the mammillary bodies, the retrosplenial cortex and parts of the prefrontal cortex. Recent neuropsychological findings reveal the disproportionate importance of these hippocampal–anterior thalamic systems for recollective rather than familiarity-based recognition, while anatomical studies highlight the precise manner in which information streams are kept separate but can also converge at key points within these pathways. These latter findings are developed further by electrophysiological stimulation studies showing how the properties of the direct hippocampal–anterior thalamic projections are often opposed by the indirect hippocampal projections via the mammillary bodies to the thalamus. Just as these hippocampal–anterior thalamic interactions reflect an interdependent system, so it is also the case that pathology in one of the component sites within this system can induce dysfunctional changes to distal sites both directly and indirectly across the system. Such distal effects challenge more traditional views of neuropathology as they reveal how extensive covert pathology might accompany localised overt pathology, and so impair memory.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Optometry and Vision Sciences Psychology Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	amnesia; fornix; hippocampus; mammillary bodies; recognition memory; spatial memory; thalamus
Publisher:	Wiley-Blackwell
ISSN:	0953-816X
Last Modified:	07 Nov 2023 11:14
URI:	https://orca.cardiff.ac.uk/id/eprint/11342

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