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Complete genome sequence and lytic phase transcription profile of a coccolithovirus

Wilson, W. H., Schroeder, Declan C., Allen, Michael J., Holden, Matthew T. G., Parkhill, Julian, Barrell, Bart G., Churcher, Carol, Hamlin, Nancy, Mungall, Karen, Norbertczak, Halina, Quail, Michael A., Price, Claire, Rabbinowitsch, Ester, Walker, Danielle, Craigon, Marie, Roy, Douglas and Ghazal, Peter ORCID: 2005. Complete genome sequence and lytic phase transcription profile of a coccolithovirus. Science 309 (5737) , pp. 1090-1092. 10.1126/science.1113109

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The genus Coccolithovirus is a recently discovered group of viruses that infect the globally important marine calcifying microalga Emiliania huxleyi. Among the 472 predicted genes of the 407,339–base pair genome are a variety of unexpected genes, most notably those involved in biosynthesis of ceramide, a sphingolipid known to induce apoptosis. Uniquely for algal viruses, it also contains six RNA polymerase subunits and a novel promoter, suggesting this virus encodes its own transcription machinery. Microarray transcriptomic analysis reveals that 65% of the predicted virus-encoded genes are expressed during lytic infection of E. huxleyi.

Item Type: Article
Date Type: Publication
Schools: Medicine
Publisher: American Association for the Advancement of Science
ISSN: 0036-8075
Date of Acceptance: 6 July 2005
Last Modified: 23 Oct 2022 14:22

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