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Annexation of the interchromosomal space during viral infection

Monier, Karine, Armas, Juan Carlos González, Etteldorf, Susanne, Ghazal, Peter ORCID: and Sullivan, Kevin F. 2000. Annexation of the interchromosomal space during viral infection. Nature Cell Biology 2 (9) , pp. 661-665. 10.1038/35023615

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The nucleus is known to be compartmentalized into units of function1, but the processes leading to the spatial organization of chromosomes and nuclear compartments are not yet well defined. Here we report direct quantitative analysis of the global structural perturbations of interphase chromosome and interchromosome domain distribution caused by infection with herpes simplex virus-1 (HSV-1). Our results show that the peripheral displacement of host chromosomes that correlates with expansion of the viral replication compartment (VRC)2,3,4,5 is coupled to a twofold increase in nuclear volume. Live cell dynamic measurements suggest that viral compartment formation is driven by the functional activity of viral components and underscore the significance of spatial regulation of nuclear activities.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Nature Publishing Group
ISSN: 1465-7392
Last Modified: 23 Oct 2022 14:27

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