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Impaired immunoproteasome assembly and immune responses in PA28/ mice

Preckel, T., Fung-Leung, Wai-Ping, Cai, Zeling, Vitiello, Antonella, Salter-Cid, Luisa, Winqvist, Ola, Wolfe, Tom G., Von Herrath, Matthias, Angulo, Ana, Ghazal, Peter, Lee, Jiing-Dwan, Fourie, Anne M., Wu, Ying, Pang, Jesse, Ngo, Karen, Peterson, Per A., Früh, Klaus and Yang, Young 1999. Impaired immunoproteasome assembly and immune responses in PA28/ mice. Science 286 (5447) , pp. 2162-2165. 10.1126/science.286.5447.2162

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Abstract

In vitro PA28 binds and activates proteasomes. It is shown here that mice with a disrupted PA28b gene lack PA28a and PA28b polypeptides, demonstrating that PA28 functions as a hetero-oligomer in vivo. Processing of antigenic epitopes derived from exogenous or endogenous antigens is altered inPA28–/– mice. Cytotoxic T lymphocyte responses are impaired, and assembly of immunoproteasomes is greatly inhibited in mice lacking PA28. These results show that PA28 is necessary for immunoproteasome assembly and is required for efficient antigen processing, thus demonstrating the importance of PA28-mediated proteasome function in immune responses

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: American Association for the Advancement of Science
ISSN: 0036-8075
Date of Acceptance: 2 November 1999
Last Modified: 20 Aug 2018 10:15
URI: https://orca.cardiff.ac.uk/id/eprint/113731

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