Contrasting hippocampal and perirhinalcortex function using immediate early gene imaging

Aggleton, John Patrick ORCID: https://orcid.org/0000-0002-5573-1308 and Brown, Malcolm 2005. Contrasting hippocampal and perirhinalcortex function using immediate early gene imaging. The Quarterly Journal of Experimental Psychology Section B 58 (3-4) , pp. 218-233. 10.1080/02724990444000131

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Abstract

The perirhinal cortex and hippocampus have close anatomical links, and it might, therefore, be predicted that they have close, interlinked roles in memory. Lesion studies have, however, often failed to support this prediction, providing dissociations and double dissociations between the two regions on tests of object recognition and spatial memory. In a series of rat studies we have compared these two regions using the expression of the immediate early gene c-fosas a marker of neuronal activity. This gene imaging approach makes it possible to assess the relative involve-ment of different brain regions and avoids many of the limitations of the lesion approach. A very consistent pattern of results was found as the various hippocampal subfields but not the peri-rhinal cortex show increased c-fosactivity following tests of spatial learning. In contrast, the perirhinal cortex but none of the hippocampal subfields show increased c-fosactivity when presented with novel rather than familiar visual objects. When novel scenes are created by the spatial rearrangement of familiar objects it is the hippocampus and not the perirhinal cortex that shows c-foschanges. This double dissociation for gene expression accords with that found from lesion studies and highlights the different contributions of the perirhinal cortex and hippocampus to memory.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Taylor & Francis
ISSN:	0272-4995
Last Modified:	18 Oct 2022 12:50
URI:	https://orca.cardiff.ac.uk/id/eprint/11375

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