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Lynch Syndrome - cancer pathways, heterogeneity and immune escape

Seth, Sidhant, Ager, Ann, Arends, Mark and Frayling, Ian M 2018. Lynch Syndrome - cancer pathways, heterogeneity and immune escape. Journal of Pathology 246 (2) , pp. 129-133. 10.1002/path.5139

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Recent work has provided evidence for genetic and molecular heterogeneity in colorectal cancers (CRCs) arising in patients with Lynch syndrome (LS), dividing these into two groups: G1 and G2. In terms of mutation and gene expression profile, G1 CRCs bear resemblance to sporadic CRCs with microsatellite instability (MSI), whereas G2 CRCs are more similar to microsatellite stable CRCs. Here we review the current state of knowledge on pathways of precursor progression to CRC in LS and how these might tie in with the new findings. Immunotherapies are an active field of research for MSI cancers and their potential use for cancer therapy for both sporadic and LS MSI cancers is discussed.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Wiley
ISSN: 0022-3417
Date of First Compliant Deposit: 1 August 2018
Date of Acceptance: 20 July 2018
Last Modified: 17 Oct 2019 19:23

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