Detection of autoantibodies to potentially amyloidogenic protein, gamma-synuclein, in the serum of patients with amyotrophic lateral sclerosis and cerebral circulatory disorders

Roman, A. Yu., Kovrazhkina, E. A., Razinskaya, O. D., Kukharsky, M. S., Maltsev, A. V., Ovchinnikov, R. K., Lytkina, O. A., Smirnov, A. P., Moskovtsev, A. A., Borodina, Yu. V., Surguchov, A. P., Ustyugov, A. A., Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 and Skvortsova, V. I. 2017. Detection of autoantibodies to potentially amyloidogenic protein, gamma-synuclein, in the serum of patients with amyotrophic lateral sclerosis and cerebral circulatory disorders. Доклады Академии Наук / Doklady Biochemistry and Biophysics 472 (1) , pp. 64-67. 10.1134/S1607672917010197

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Abstract

In this study, we analyzed serum for the presence of antibodies to gamma-synuclein in patients with amyotrophic lateral sclerosis (ALS) compared to the control group of patients with other neurological diseases and healthy control donors. As a result, antibodies against gamma-synuclein are not an ALS-specific feature and have been identified in patients with ALS as well as in the control group patients. Patients with the impaired cerebral circulation showed increased incidence of autoantibodies to gamma-synuclein, yet the difference lacks statistical representativeness due to limited sample size.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Biosciences
Publisher:	MAIK Nauka/Interperiodica
ISSN:	1607-6729
Date of First Compliant Deposit:	2 August 2018
Date of Acceptance:	16 April 2016
Last Modified:	24 Oct 2022 07:00
URI:	https://orca.cardiff.ac.uk/id/eprint/113854

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