Physiological evidence for a possible projection from dorsal subiculum to hippocampal area CA1

Commins, Sean, Aggleton, John Patrick ORCID: https://orcid.org/0000-0002-5573-1308 and O'Mara, Shane M. 2002. Physiological evidence for a possible projection from dorsal subiculum to hippocampal area CA1. Experimental Brain Research 146 (2) , pp. 155-160. 10.1007/s00221-002-1158-x

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Abstract

The substantial forward projection from hippocampal area CA1 to the subiculum has been comprehensively described, both anatomically and neurophysiologically. There are few data, however, regarding the existence of a backward projection from the subiculum to area CA1. We present here new electrophysiological evidence for the existence of this projection. We demonstrate a positive-going deflection in the evoked synaptic response in area CA1 following stimulation in dorsal subiculum. We also found a small, but significant, paired-pulse facilitatory effect at a 100-ms interstimulus interval. We were unable to induce long-term potentiation following high-frequency stimulation, but were able to induce short-term potentiation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Psychology Schools > Medicine Research Institutes & Centres > Neuroscience and Mental Health Research Institute (NMHII)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Subiculum - CA1 - Paired-pulse facilitation - Long-term potentiation - Short-term potentiation
Publisher:	Springer
ISSN:	0014-4819
Last Modified:	18 Oct 2022 12:50
URI:	https://orca.cardiff.ac.uk/id/eprint/11390

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