Excitotoxic lesions of the rostral thalamic reticular nucleus do not affect the performance of spatial learning and memory tasks in the rat

Wilton, L. A. K., Baird, Alison Lambie, Muir, Janice L. and Aggleton, John Patrick ORCID: https://orcid.org/0000-0002-5573-1308 2001. Excitotoxic lesions of the rostral thalamic reticular nucleus do not affect the performance of spatial learning and memory tasks in the rat. Behavioural Brain Research 120 (2) , pp. 177-187. 10.1016/S0166-4328(00)00369-7

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Abstract

Rats with cytotoxic lesions of the rostral pole of the thalamic reticular nucleus were compared with surgical control animals on a series of spatial learning and memory tests. While evidence was found for an initial, transient impairment on forced-choice alternation in a T-maze, this rapidly disappeared, and overall performance was unaffected. Subsequent experiments found no evidence that lesions of the rostral reticular nucleus affected the acquisition or performance of tests in the radial arm maze and the Morris water maze. Thus, it appears that the rostral pole of the thalamic reticular nucleus often does not play a necessary role in the performance of tests of spatial learning and memory, in spite of its interconnections with other regions that are required for normal spatial memory.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Psychology Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Anterior thalamic nuclei; Attention; Rat; Spatial memory; Thalamic reticular nucleus
Publisher:	Elsevier
ISSN:	0166-4328
Last Modified:	18 Oct 2022 12:50
URI:	https://orca.cardiff.ac.uk/id/eprint/11399

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