Loss of the thalamic nuclei for "head direction" impairs performance on spatial memory tasks in rats

Wilton, L. A. K., Baird, Alison Lambie, Muir, Janice L., Honey, Robert Colin ORCID: https://orcid.org/0000-0001-6870-1880 and Aggleton, John Patrick ORCID: https://orcid.org/0000-0002-5573-1308 2001. Loss of the thalamic nuclei for "head direction" impairs performance on spatial memory tasks in rats. Behavioral Neuroscience 115 (4) , pp. 861-869. 10.1037/0735-7044.115.4.861

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Abstract

This study sought to characterize the effects of removing the nuclei of primary importance in relaying the thalamic head direction signal to the hippocampal formation (the anterior dorsal [AD] and lateral dorsal [LD] nuclei) on the performance of a variety of spatial and nonspatial tasks. The results indicate that combined excitotoxic lesions of the AD and LD nuclei produce marked deficits on a variety of spatial tasks. These tasks included T-maze alternation and the ability to locate a hidden platform set at a fixed distance and fixed direction from a beacon in a Morris water maze. Although object recognition appeared unaffected, marked impairments were found in the ability to detect when an object was placed in a novel position (object-in-place memory).

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Psychology Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	American Psychological Association
ISSN:	0735-7044
Last Modified:	18 Oct 2022 12:50
URI:	https://orca.cardiff.ac.uk/id/eprint/11400

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