Meyer's loop tractography for image-guided surgery depends on imaging protocol and hardware

Chamberland, Maxime ORCID: https://orcid.org/0000-0001-7064-0984, Tax, Chantal M. W. ORCID: https://orcid.org/0000-0002-7480-8817 and Jones, Derek K. ORCID: https://orcid.org/0000-0003-4409-8049 2018. Meyer's loop tractography for image-guided surgery depends on imaging protocol and hardware. NeuroImage: Clinical 20 , pp. 458-465. 10.1016/j.nicl.2018.08.021

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Abstract

Introduction Surgical resection is an effective treatment for temporal lobe epilepsy but can result in visual field defects. This could be minimized if surgeons knew the exact location of the anterior part of the optic radiation (OR), the Meyer's loop. To this end, there is increasing prevalence of image-guided surgery using diffusion MRI tractography. Despite considerable effort in developing analysis methods, a wide discrepancy in Meyer's loop reconstructions is observed in the literature. Moreover, the impact of differences in image acquisition on Meyer's loop tractography remains unclear. Here, while employing the same state-of-the-art analysis protocol, we explored the extent to which variance in data acquisition leads to variance in OR reconstruction. Methods Diffusion MRI data were acquired for the same thirteen healthy subjects using standard and state-of-the-art protocols on three scanners with different maximum gradient amplitudes (MGA): Siemens Connectom (MGA = 300 mT/m); Siemens Prisma (MGA = 80 mT/m) and GE Excite-HD (MGA = 40 mT/m). Meyer's loop was reconstructed on all subjects and its distance to the temporal pole (ML-TP) was compared across protocols. Results A significant effect of data acquisition on the ML-TP distance was observed between protocols (p < .01 to 0.0001). The biggest inter-acquisition discrepancy for the same subject across different protocols was 16.5 mm (mean: 9.4 mm, range: 3.7–16.5 mm). Conclusion We showed that variance in data acquisition leads to substantive variance in OR tractography. This has direct implications for neurosurgical planning, where part of the OR is at risk due to an under-estimation of its location using conventional acquisition protocols.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher:	Elsevier
ISSN:	2213-1582
Funders:	Wellcome Trust, Engineering and Physical Sciences Research Council
Date of First Compliant Deposit:	14 August 2018
Date of Acceptance:	10 August 2018
Last Modified:	11 Oct 2023 17:14
URI:	https://orca.cardiff.ac.uk/id/eprint/114146

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