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Short total synthesis of ajoene

Silva, Filipa, Khokhar, Shaista S., Williams, Danielle M., Saunders, Robert, Evans, Gareth J. S., Graz, Michael and Wirth, Thomas ORCID: 2018. Short total synthesis of ajoene. Angewandte Chemie International Edition 57 (38) , pp. 12290-12293. 10.1002/anie.201808605

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We describe a short total synthesis of ajoene, a major biologically active constituent of garlic. The instability of allicin as the only other known alternative starting material has led to the development of a reliable protocol for the synthesis of ajoene from simple building blocks also suitable for upscale operations.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Publisher: Wiley
ISSN: 1433-7851
Funders: EPSRC
Date of First Compliant Deposit: 15 August 2018
Date of Acceptance: 6 August 2018
Last Modified: 05 May 2023 01:04

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