FLP-catalyzed transfer hydrogenation of silyl enol ethers

Khan, Imtiaz, Reed-Berendt, Benjamin G., Melen, Rebecca L. ORCID: https://orcid.org/0000-0003-3142-2831 and Morrill, Louis C. ORCID: https://orcid.org/0000-0002-6453-7531 2018. FLP-catalyzed transfer hydrogenation of silyl enol ethers. Angewandte Chemie International Edition 57 (38) , pp. 12356-12359. 10.1002/anie.201808800

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Abstract

Herein we report the first catalytic transfer hydrogenation of silyl enol ethers. This metal free approach employs tris(pentafluorophenyl)borane and 2,2,6,6‐tetramethylpiperidine (TMP) as a commercially available FLP catalyst system and naturally occurring γ‐terpinene as a dihydrogen surrogate. A variety of silyl enol ethers undergo efficient hydrogenation, with the reduced products isolated in excellent yields (29 examples, 82% average yield).

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Chemistry
Publisher:	Wiley
ISSN:	1433-7851
Funders:	Engineering and Physical Sciences Research Council
Date of First Compliant Deposit:	15 August 2018
Date of Acceptance:	14 August 2018
Last Modified:	23 Sep 2023 20:56
URI:	https://orca.cardiff.ac.uk/id/eprint/114187

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