Extensive cytotoxic lesions involving both the rhinal cortices and area TE impair recognition but spare spatial alternation in the rat

Aggleton, John ORCID: https://orcid.org/0000-0002-5573-1308, Keen, S., Warburton, E. C. and Bussey, T. J. 1997. Extensive cytotoxic lesions involving both the rhinal cortices and area TE impair recognition but spare spatial alternation in the rat. Brain Research Bulletin 43 (3) , pp. 279-287. 10.1016/S0361-9230(97)00007-5

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Abstract

Rats with cytotoxic lesions of the perirhinal, postrhinal, and TE cortices (Rh+TE, n = 7) were compared with surgical control animals (n = 7) on a series of spontaneous object recognition tests. The Rh+TE group was associated with a failure to select the novel object. This recognition deficit contrasted with the apparently normal ability of the same animals to learn and perform a spatial working memory test (T-maze alternation). The animals were also tested on the acquisition of an automated visual discrimination task in which the stimuli were presented on a visual display unit (VDU) equipped with a touch screen. The animals with Rh+TE lesions showed only a borderline deficit on this task. These findings are consistent with other evidence implicating the rhinal region in recognition memory. More importantly, they also provide a dissociation between spatial working memory and object recognition and, hence, show that extensive rhinal lesions are not sufficient to disconnect the hippocampus functionally.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology
Uncontrolled Keywords:	Perirhinal cortex ; Spatial memory ; Object recognition ; Learning ; Memory ; Rat
Publisher:	Elsevier
ISSN:	0361-9230
Last Modified:	18 Oct 2022 12:51
URI:	https://orca.cardiff.ac.uk/id/eprint/11435

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