Effects of the novelty or familiarity of visual stimuli on the expression of the immediate early gene c-fos in rat brain

Zhu, X. O., Brown, M. W., McCabe, B. J. and Aggleton, John Patrick ORCID: https://orcid.org/0000-0002-5573-1308 1995. Effects of the novelty or familiarity of visual stimuli on the expression of the immediate early gene c-fos in rat brain. Neuroscience 69 (3) , pp. 821-829. 10.1016/0306-4522(95)00320-I

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Abstract

Abstract--To investigate substrates of recognition memory, the cellular expression of Fos protein in rat brain has been studied after groups of rats were either shown sets of novel or highly familiar objects, or were exposed to the same pattern of illumination without objects being shown. Counts of stained nuclei were made in eight brain regions, where information about novel or familiar visual stimuli is likely to be processed or stored. The counts were relatively high in occipital visual association cortex and area TE of temporal cortex, intermediate in perirhinal cortex, entorhinal cortex, anterior cingulate cortex and the diagonal band of Broca, and low in the hippocampal formation and mediodorsal nucleus of the thalamus. The number of Fos-stained cells was significantly higher for the rats shown novel objects than for those shown familiar objects in perirhinal cortex, area TE, occipital cortex and anterior cingulate cortex. Arguments are advanced that these differences in counts indicate areas involved in the processing and/or storage of information about the novelty or familiarity of visual stimuli, information important to recognition memory.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	learning ; memory ; recognition ; visual cortex ; rhinal cortex ; hippocampus ; prefrontal cortex ; thalamus.
ISSN:	0306-4522
Last Modified:	18 Oct 2022 12:51
URI:	https://orca.cardiff.ac.uk/id/eprint/11440

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