Obstetric consequences of subfertility: a retrospective cohort study

DoPierala, AL, Bhatta, S, Raja, EA, Bhattacharya, S ORCID: https://orcid.org/0000-0002-4588-356X and Bhattacharya, S ORCID: https://orcid.org/0000-0002-4588-356X 2016. Obstetric consequences of subfertility: a retrospective cohort study. BJOG: An International Journal of Obstetrics and Gynaecology 123 (8) , pp. 1320-1328. 10.1111/1471-0528.13584

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Abstract

Objective To compare the risk of adverse pregnancy outcomes in women with and without subfertility and to investigate whether fertility treatment contributes to the adverse outcomes. Design Register‐based retrospective cohort study. Setting Aberdeen, Scotland Population The exposed group included women with subfertility attending Aberdeen Fertility Clinic between 1989 and 2008 and delivering a singleton (n = 3188) or twin (n = 350) at Aberdeen Maternity Hospital between 1992 and 2009. The unexposed cohort included the remainder of women (singleton n = 52443, twin n = 1125) delivering at Aberdeen Maternity Hospital between 1992 and 2009. Methods The Aberdeen Fertility Centre database and Aberdeen Maternity and Neonatal Databank were linked using Community Health Index numbers. Regression models were used to calculate risk ratios and 95% confidence intervals adjusting for potential confounders. Main outcome measures Maternal outcomes including pre‐eclampsia, antepartum haemorrhage, preterm birth, induction of labour; delivery outcomes including operative vaginal delivery, caesarean section; and offspring outcomes including low birthweight, stillbirth and neonatal death. Results Women with a history of subfertility who delivered a singleton were at a higher risk of pre‐eclampsia [adjusted risk ratios (aRR) 1.18, 95% confidence intervals (CI) 1.02–1.37], antepartum haemorrhage (aRR 1.32, 95% CI 1.18–1.47), induction of labour (aRR 1.21, 95% CI 1.11–1.31) and very preterm delivery (<32 weeks) (aRR 1.96, 95% CI 1.53–2.49). Subfertile women delivering twins were at a higher risk of being delivered by emergency caesarean section (aRR 2.14, 95% CI 1.26–3.66). There were no significant differences in adverse outcomes for singleton pregnancies between the treated and untreated subfertile couples. Conclusion Subfertility per se, rather than fertility treatment, was associated with increased risk of adverse outcomes in singleton pregnancies.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Wiley
ISSN:	1470-0328
Date of First Compliant Deposit:	28 August 2018
Date of Acceptance:	2 July 2015
Last Modified:	07 Nov 2024 03:15
URI:	https://orca.cardiff.ac.uk/id/eprint/114416

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