Oxygen producing microscale spheres affect cell survival in conditions of oxygen-glucose deprivation in a cell specific manner: implications for cell transplantation

Newland, Heike ORCID: https://orcid.org/0000-0002-5214-2604, Eigel, Dimitri, Rosser, Anne E. ORCID: https://orcid.org/0000-0002-4716-4753, Werner, Carsten and Newland, Ben ORCID: https://orcid.org/0000-0002-5214-2604 2018. Oxygen producing microscale spheres affect cell survival in conditions of oxygen-glucose deprivation in a cell specific manner: implications for cell transplantation. Biomaterials Science 6 (10) , pp. 2571-2577. 10.1039/C8BM00490K

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Abstract

This study outlines the synthesis of microscale oxygen producing spheres, which, when used in conjunction with catalase, can raise the dissolved oxygen content of cell culture media for 16–20 hours. In conditions of oxygen and glucose deprivation, designed to mimic the graft environment in vivo, the spheres rescue SH-SY5Y cells and meschymal stem cells, showing that oxygen producing biomaterials may hold potential to improve the survival of cells post-transplantation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy Biosciences
Publisher:	Royal Society of Chemistry
ISSN:	2047-4830
Date of First Compliant Deposit:	29 August 2018
Date of Acceptance:	27 June 2018
Last Modified:	15 Nov 2023 12:25
URI:	https://orca.cardiff.ac.uk/id/eprint/114474

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