Bronchial hyper-responsiveness in preterm-born subjects: A systematic review and meta-analysis

Kotecha, Sailesh ORCID: https://orcid.org/0000-0003-3535-7627, Clemm, Hege, Halvorsen, Thomas and Kotecha, Sarah J. 2018. Bronchial hyper-responsiveness in preterm-born subjects: A systematic review and meta-analysis. Pediatric Allergy and Immunology 29 (7) , pp. 715-725. 10.1111/pai.12957

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Abstract

Background Preterm‐born survivors have increased respiratory symptoms and decreased lung function, but the nature of bronchial hyper‐responsiveness (BHR) is unclear. We conducted a systematic review and meta‐analysis for BHR in preterm‐born survivors including those with and without chronic lung disease in infancy (CLD) comparing results to term‐born subjects. Methods We searched eight databases up to December 2016. Included articles compared BHR in preterm‐born and term‐born subjects. Studies reporting BHR as decreases in forced expiratory volume in 1 second (FEV1) after provocation stimuli were included. The analysis used Review Manager V5.3. Results From 10 638 titles, 265 full articles were screened, and 28 included in a descriptive analysis. Eighteen articles were included in a meta‐analysis as they reported the proportion of subjects who had BHR. Pooled odds ratio (OR) estimates (95% confidence interval) for BHR comparing the preterm and term‐born groups was 1.88 (1.32, 2.66). The majority of the studies reported BHR after a methacholine challenge or an exercise test. Odds ratio was 1.89 (1.12, 3.19) after methacholine challenge and 2.59 (1.50, 4.50) after an exercise test. Nine of fifteen articles reporting BHR in CLD subjects were included in a meta‐analysis. Differences for BHR including for methacholine (OR 4.35; 2.36, 8.03) and exercise (OR 5.13; 1.82, 14.47) were greater in the CLD group compared to the term group. Conclusions Preterm‐born subjects especially those who had CLD had increased rates of BHR to direct (methacholine) and indirect (exercise) stimuli compared to term‐born subjects suggesting subgroups might benefit from anti‐inflammatory or bronchodilator therapies.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Additional Information:	This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Publisher:	Wiley
ISSN:	0905-6157
Funders:	Medical Research Council
Date of First Compliant Deposit:	29 August 2018
Date of Acceptance:	11 June 2018
Last Modified:	04 May 2023 23:37
URI:	https://orca.cardiff.ac.uk/id/eprint/114480

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