Memory impairments following restricted thalamic lesions in monkeys [Abstract]

Aggleton, John Patrick ORCID: https://orcid.org/0000-0002-5573-1308 and Mishkin, M. 1984. Memory impairments following restricted thalamic lesions in monkeys [Abstract]. Behavioural Brain Research 12 (2) , p. 165. 10.1016/0166-4328(84)90039-1

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Abstract

Thalamic contributions to memory were assessed in monkeys with lesions placed in the medial portions of either the anterior or posterior thalamus (AMT and PMT respectively). Nine cynomolgus monkeys (Macaca fascicularis) were trained on a recognition task which required the animal to select a novel object in preference to a sample object which had been presented to the monkey 10s earlier. Three monkeys then received surgical lesions centred in the anterior nuclei (AMT) and three received lesions centred in nucleus medialis dorsalis (PMT). Although the experimental monkeys rapidly relearned this task of object recognition, both the AMT and PMT groups performed significantly worse than the unoperated control monkeys when the task was made harder by requiring the animals to distinguish the sample objects after increasing delays (30s, 60s, 120s) or after additional intervening objects (3, 5, and then 10). Furthermore, all three PMT animals and two of the AMT group were moderately impaired on a test of object-reward association memory in which the animals had to remember which of two sample objects had been previously paired with a good reward. Comparison of these results with those of a previous study in which the AMT and PMT regions were removed jointly suggests that damage in either region can induce a memory loss but that combined damage to both is required to produce the full amnesia.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Additional Information:	Abstract of the annual general conference of the European Brain and Behaviour Society held in Marseille, France on September 22nd–24th, 1983
Publisher:	Elsevier
ISSN:	0166-4328
Last Modified:	18 Oct 2022 12:52
URI:	https://orca.cardiff.ac.uk/id/eprint/11456

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