Dürüst, Yasar, Karakus, Hamza, Kariuki, Benson M. ![]() |
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Abstract
In situ generated 2,4-diaryl substituted münchnones from 2-(4-substitutedphenyl)-2-(N-methyl-N-4-substitutedbenzamido)acetic acids react with acetic anhydride in the presence of 2-nitromethylene thiazolidine, which is most likely acting as a base, and unexpectedly undergo a Dakin–West type reaction and a concurrent autoxidation reaction leading to the formation of (E)-1-(N,4-dimethylbenzamido)-1-(4-fluorophenyl)prop-1-en-2-yl acetate, 4-substitutedphenyl-N-methyl-N-(4-substitutedbenzoyl) benzamides and p-substituted benzoic acids. In addition, a novel and efficient access to N-acyl urea derivatives is described by the reaction between 2-(4-substitutedphenyl)-2-(N-methyl-N-4-substitutedbenzamido)acetic acids and cyclohexyl, isopropyl carbodiimides in the presence of a base. The structures of all new products were identified on the basis of NMR and IR spectra, along with X-ray diffraction data and HRMS measurements.
Item Type: | Article |
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Date Type: | Published Online |
Status: | Published |
Schools: | Chemistry |
Publisher: | Taylor & Francis: STM, Behavioural Science and Public Health Titles |
ISSN: | 0039-7911 |
Date of First Compliant Deposit: | 1 October 2018 |
Date of Acceptance: | 9 July 2018 |
Last Modified: | 16 Nov 2024 01:15 |
URI: | https://orca.cardiff.ac.uk/id/eprint/115387 |
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