Triantafilou, Kathy  ORCID: https://orcid.org/0000-0002-7473-6278, Kar, Satwik, van Kuppeveld, Frank J. M. and Triantafilou, Martha ORCID: https://orcid.org/0000-0002-7473-6278
2013.
Rhinovirus-induced calcium flux triggers NLRP3 and NLRC5 activation in bronchial cells.
American Journal of Respiratory Cell and Molecular Biology
49
(6)
, p. 923.
10.1165/rcmb.2013-0032OC
|
Abstract
Human rhinoviruses have been linked with underlying lung disorders, such as asthma and chronic obstructive pulmonary disease, in children and adults. However, the mechanism of virus-induced airway inflammation is poorly understood. In this study, using virus deletion mutants and silencing for nucleotide-binding oligomerization domain–like receptors (NLRs), we show that the rhinovirus ion channel protein 2B triggers NLRP3 and NLRC5 inflammasome activation and IL-1β secretion in bronchial cells. 2B protein targets the endoplasmic reticulum and Golgi and induces Ca2+ reduction in these organelles, thereby disturbing the intracellular calcium homeostasis. NLRP3 and NLRC5 act in a cooperative manner during the inflammasome assembly by sensing intracellular Ca2+ fluxes and trigger IL-1β secretion. These results reveal for the first time that human rhinovirus infection in primary bronchial cells triggers inflammasome activation.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine |
| Publisher: | American Thoracic Society |
| ISSN: | 1044-1549 |
| Date of Acceptance: | 10 June 2013 |
| Last Modified: | 24 Oct 2022 07:37 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/115428 |
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