Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in the bile acid-farnesoid X receptor-fibroblast growth factor pathway

Monaghan, Tanya, Mullish, Benjamin H, Patterson, Jordan, Wong, Gane K S, Marchesi, Julian R. ORCID: https://orcid.org/0000-0002-7994-5239, Xu, Huiping, Jilani, Tahseen and Kao, Dina 2019. Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in the bile acid-farnesoid X receptor-fibroblast growth factor pathway. Gut Microbes 10 (2) , pp. 142-148. 10.1080/19490976.2018.1506667

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Abstract

The mechanisms of efficacy for fecal microbiota transplantation (FMT) in treating recurrent Clostridioides difficile infection (rCDI) remain poorly defined, with restored gut microbiota-bile acid interactions representing one possible explanation. Furthermore, the potential implications for host physiology of these FMT-related changes in gut bile acid metabolism are also not well explored. In this study, we investigated the impact of FMT for rCDI upon signalling through the farnesoid X receptor (FXR)-fibroblast growth factor (FGF) pathway. Herein, we identify that in addition to restoration of gut microbiota and bile acid profiles, FMT for rCDI is accompanied by a significant, sustained increase in circulating levels of FGF19 and reduction in FGF21. These FGF changes were associated with weight gain post-FMT, to a level not exceeding the pre-rCDI baseline. Collectively, these data support the hypothesis that the restoration of gut microbial communities by FMT for rCDI is associated with an upregulated FXR-FGF pathway, and highlight the potential systemic effect of FMT.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Landes Bioscience
ISSN:	1949-0976
Date of First Compliant Deposit:	2 October 2018
Date of Acceptance:	25 July 2018
Last Modified:	04 May 2023 20:28
URI:	https://orca.cardiff.ac.uk/id/eprint/115466

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