Robustly measuring vascular reactivity differences with breath-hold: Normalising stimulus-evoked and resting state BOLD fMRI data

Murphy, Kevin ORCID: https://orcid.org/0000-0002-6516-313X, Harris, Ashley D. and Wise, Richard Geoffrey ORCID: https://orcid.org/0000-0003-1700-2144 2011. Robustly measuring vascular reactivity differences with breath-hold: Normalising stimulus-evoked and resting state BOLD fMRI data. NeuroImage 54 (1) , pp. 369-379. 10.1016/j.neuroimage.2010.07.059

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Abstract

Inter-subject differences in local cerebral blood flow (CBF) and cerebral blood volume (CBV) contribute to differences in BOLD signal reactivity and, therefore, unmodelled variance in group level fMRI analyses. A simple way of elevating blood CO2 concentrations to characterise subject differences in vascular reactivity is through breath-holds but two aspects of this measure are often neglected: (1) breath-holds are usually modelled as blocks even though CO2 accumulates over time and (2) increases in CO2 differ between subjects. This study demonstrates that the BOLD breath-hold response is best modelled by convolving the end-tidal CO2 trace with a standard haemodynamic response function and including its temporal derivative. Inclusion of the BOLD breath-hold response as a voxel-dependent covariate in a group level analysis increases the spatial extent of activation in stimulus evoked and resting state datasets. By expressing the BOLD breath-hold response as a percentage signal increase with respect to an absolute change in the partial pressure of CO2 (expressed in mmHg), the spatial extent of stimulus-evoked activation is further improved. This demonstrates that individual end-tidal CO2 increases to breath-hold should be accounted for to provide an accurate measure of vascular reactivity resulting in more statistically active voxels in group level analyses.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Research Institutes & Centres > Neuroscience and Mental Health Research Institute (NMHII) Schools > Psychology Research Institutes & Centres > Cardiff University Brain Research Imaging Centre (CUBRIC) Schools > Physics and Astronomy
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Elsevier
ISSN:	1053-8119
Last Modified:	03 May 2025 13:59
URI:	https://orca.cardiff.ac.uk/id/eprint/11595

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