Establishing the transitory existence of amorphous phases in crystallization pathways by the CLASSIC NMR technique

Hughes, Colan E, Williams, Andrew, Kariuki, Benson M ORCID: https://orcid.org/0000-0002-8658-3897 and Harris, Kenneth David Maclean ORCID: https://orcid.org/0000-0001-7855-8598 2018. Establishing the transitory existence of amorphous phases in crystallization pathways by the CLASSIC NMR technique. ChemPhysChem 19 (24) , pp. 3341-3345. 10.1002/cphc.201800976

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Abstract

With the growing realization that crystallization processes may evolve through a sequence of different solid forms, including amorphous precursor phases, the development of suitable in situ experimental probes is essential for comprehensively mapping the time‐evolution of such processes. Here we demonstrate that the CLASSIC NMR (Combined Liquid‐ And Solid‐State In situ Crystallization NMR) strategy is a powerful technique for revealing the transitory existence of amorphous phases during crystallization processes, applying this technique to study crystallization of DL menthol and L menthol from their molten liquid phases. The CLASSIC NMR results provide direct insights into the conditions (including the specific time period) under which the molten liquid phase, transitory amorphous phases and final crystalline phases exist during these crystallization processes.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry Advanced Research Computing @ Cardiff (ARCCA)
Publisher:	Wiley-VCH Verlag
ISSN:	1439-4235
Date of First Compliant Deposit:	23 October 2018
Date of Acceptance:	22 October 2018
Last Modified:	21 Nov 2024 05:45
URI:	https://orca.cardiff.ac.uk/id/eprint/116121

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