Absence of neuronal response modulation with familiarity in perirhinal cortex

Baruchin, Liad J., Ranson, Adam ORCID: https://orcid.org/0000-0002-4804-0832, Good, Mark ORCID: https://orcid.org/0000-0002-1824-1203 and Crunelli, Vincenzo ORCID: https://orcid.org/0000-0001-7154-9752 2018. Absence of neuronal response modulation with familiarity in perirhinal cortex. Neuroscience 394 , pp. 23-29. 10.1016/j.neuroscience.2018.10.020

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Abstract

The perirhinal cortex (PRH) is considered a crucial cortical area for familiarity memory and electrophysiological studies have reported the presence of visual familiarity encoding neurons in PRH. However, recent evidence has questioned the existence of these neurons. Here, we used a visual task in which head-restrained mice were passively exposed to oriented gratings or natural images. Evoked potentials and single-unit recordings showed evoked responses to novelty in V1 under some conditions. However, the PRH showed no response modulation with respect to familiarity under a variety of different conditions or retention delays. These results indicate that the PRH does not contribute to familiarity/novelty encoding using passively exposed visual stimuli.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Medicine Psychology
Publisher:	Elsevier
ISSN:	0306-4522
Date of First Compliant Deposit:	24 October 2018
Date of Acceptance:	10 October 2018
Last Modified:	23 Oct 2023 06:20
URI:	https://orca.cardiff.ac.uk/id/eprint/116133

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