Near full-length sequence analysis of HIV Type 1 BF recombinants from Italy

Saladini, Francesco, Foley, Brian T., Rosi, Andrea, Vicenti, Ilaria, Nannetti, Giulio ORCID: https://orcid.org/0000-0003-3227-1537, Meini, Genny, Razzolini, Francesca and Zazzi, Maurizio 2012. Near full-length sequence analysis of HIV Type 1 BF recombinants from Italy. AIDS Research and Human Retroviruses 28 (3) , p. 299. 10.1089/aid.2011.0002

Preview

PDF - Accepted Post-Print Version Download (205kB) | Preview

Abstract

Recombination between HIV-1 subtypes B and F has generated several circulating and unique recombinant forms, particularly in Latin American areas. In Italy, subtype B is highly prevalent while subtype F is the most common pure non-B subtype. To investigate the recombination pattern in Italian BF recombinant viruses, we characterized full-length sequences derived from 15 adult patients, mostly Italian and infected by the heterosexual route. One of the BF mosaics was a CRF29, three sequences clustered with low bootstrap values with CRF39, CRF40, and CRF42. With the exception of the CRF29-like sequence, the other recombination patterns were unique, but two possible clusters were identified. Analysis of the gp120 V3 domain suggested a possible link with subtype F from Eastern Europe rather than from Latin America, favoring the hypothesis of local recombination between clade B and F viruses over that of import of BF recombinants from Latin America. HIV-1 subtypes B and F appear prone to generation of unique recombinants in Italy, warranting epidemiological surveillance and investigation of a possible clinical significance.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Pharmacy
Publisher:	Mary Ann Liebert
ISSN:	0889-2229
Date of First Compliant Deposit:	29 October 2018
Last Modified:	14 Nov 2024 07:45
URI:	https://orca.cardiff.ac.uk/id/eprint/116279

Citation Data

Cited 3 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item