Nanoporous aluminosilicate-catalyzed telescoped acetalization-direct aldol reactions of acetals with 1,3-dicarbonyl compounds

Davies, Thomas Edward, Taylor, Stuart H. ORCID: https://orcid.org/0000-0002-1933-4874 and Graham, Andrew Edward 2018. Nanoporous aluminosilicate-catalyzed telescoped acetalization-direct aldol reactions of acetals with 1,3-dicarbonyl compounds. ACS Omega 3 (11) , pp. 15482-15491. 10.1021/acsomega.8b02047

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Abstract

Nanoporous aluminosilicate materials, synthesized by an evaporation-induced self-assembly process, catalyze the direct aldol reaction of acyclic acetals with a range of 1,3-dicarbonyl compounds to produce the corresponding aldol addition products in high yield, rather than the expected Knoevenagel elimination products. By carrying out the reaction in the presence of either dimethoxy propane or the corresponding orthoester, it is possible to capitalize on the ability of these aluminosilicate materials to catalyze the corresponding acetalization reaction leading to the development of novel telescoped, acetalization-direct aldol addition reaction protocols.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry Cardiff Catalysis Institute (CCI)
Publisher:	American Chemical Society
ISSN:	2470-1343
Funders:	EPSRC
Date of First Compliant Deposit:	15 November 2018
Date of Acceptance:	1 November 2018
Last Modified:	14 Nov 2024 08:42
URI:	https://orca.cardiff.ac.uk/id/eprint/116832

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