Lepletier, Ailin, Lutzky, Viviana P, Mittal, Deepak, Stannard, Kimberley, Watkins, Thomas S, Ratnatunga, Champa N, Smith, Corey, McGuire, Helen M, Kemp, Roslyn A, Mukhopadhyay, Pamela, Waddell, Nicola, Smyth, Mark J, Dougall, William C and Miles, John
2019.
The immune checkpoint CD96 defines a distinct lymphocyte phenotype and is highly expressed on tumor-infiltrating T cells.
Immunology and Cell Biology
97
(2)
, pp. 152-164.
10.1111/imcb.12205
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Abstract
CD96 has recently been shown to be a potent immune checkpoint molecule in mice, but a similar role in humans is not known. In this study, we provide a detailed map of CD96 expression across human lymphocyte lineages, the kinetics of CD96 regulation on T-cell activation and co-expression with other conventional and emerging immune checkpoint molecules. We show that CD96 is predominantly expressed by T cells and has a unique lymphocyte expression profile. CD96 high T cells exhibited distinct effector functions on activation. Of note, CD96 expression was highly correlated with T-cell markers in primary and metastatic human tumors and was elevated on antigen- experienced T cells and tumor-infiltrating lymphocytes. Collectively, these data demonstrate that CD96 may be a promising immune checkpoint to enhance T-cell function against human cancer and infectious disease
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine |
| Publisher: | Nature Publishing Group |
| ISSN: | 0818-9641 |
| Date of First Compliant Deposit: | 17 June 2019 |
| Date of Acceptance: | 13 September 2018 |
| Last Modified: | 20 Nov 2024 20:15 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/117667 |
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