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Organometallic gold-based anticancer therapeutics

Casini, Angela ORCID:, Bonsignore, Riccardo ORCID: and Oberkofler, Jens 2018. Organometallic gold-based anticancer therapeutics. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering, Elsevier, pp. 1-10. (10.1016/B978-0-12-409547-2.14350-1)

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The application of gold in medicine is traceable for several thousand years, and recently, research into gold-based drugs for a number of human diseases has seen a renaissance. Within this research area, organometallic gold complexes have been particularly explored as anticancer therapeutics, mainly due to their higher stability in physiological conditions guaranteed by the presence of a direct Au-C bond. In this specialized contribution, a selection of the main results obtained on the synthesis, chemical properties and biological activities of two of the most explored families of organometallics—namely, Au(I) N-heterocyclic carbenes (NHCs) and cyclometalated Au(III) compounds—is presented. Their structure-activity relationships and information on their modes of action are also discussed, which constitute the basis for future drug design.

Item Type: Book Section
Date Type: Published Online
Status: Published
Schools: Chemistry
Publisher: Elsevier
ISBN: 9780124095472
Date of First Compliant Deposit: 20 December 2018
Date of Acceptance: 22 October 2018
Last Modified: 23 Jan 2024 08:55

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