Disease map-based biomarker selection and pre-validation for bladder cancer diagnostic

De Paoli, Marine, Perco, Paul, Mühlberger, Irmgard, Lukas, Arno, Pandha, Hardev, Morgan, Richard, Feng, Gui Jie and Marquette, Christophe 2015. Disease map-based biomarker selection and pre-validation for bladder cancer diagnostic. Biomarkers 20 (5) , pp. 328-337. 10.3109/1354750X.2015.1068867

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Abstract

Context: Urinary biomarkers are promising as simple alternatives to cystoscopy for the diagnosis of de novo and recurrent bladder cancer. Objective: To identify a highly sensitive and specific biomarker candidate set with potential clinical utility in bladder cancer. Materials and methods: Urinary biomarker concentrations were determined by ELISA. The performance of individual markers and marker combinations was assessed using ROC analysis. Results: A five-biomarker panel (IL8, MMP9, VEGFA, PTGS2 and EN2) was defined from the candidate set. Discussion and conclusion: This panel showed a better overall performance than the best individual marker. Further validation studies are needed to evaluate its clinical utility in bladder cancer.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Medicine
Publisher:	Taylor & Francis: STM, Behavioural Science and Public Health Titles
ISSN:	1354-750X
Date of Acceptance:	10 June 2015
Last Modified:	09 Oct 2019 13:17
URI:	https://orca.cardiff.ac.uk/id/eprint/118468

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