Synthetic epigenetics-towards intelligent control of epigenetic states and cell identity

Jurkowski, Tomasz P ORCID: https://orcid.org/0000-0002-2012-0240, Ravichandran, Mirunalini and Stepper, Peter 2015. Synthetic epigenetics-towards intelligent control of epigenetic states and cell identity. Clinical Epigenetics 7 , p. 18. 10.1186/s13148-015-0044-x

Preview

PDF - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview

Abstract

Epigenetics is currently one of the hottest topics in basic and biomedical research. However, to date, most of the studies have been descriptive in nature, designed to investigate static distribution of various epigenetic modifications in cells. Even though tremendous amount of information has been collected, we are still far from the complete understanding of epigenetic processes, their dynamics or even their direct effects on local chromatin and we still do not comprehend whether these epigenetic states are the cause or the consequence of the transcriptional profile of the cell. In this review, we try to define the concept of synthetic epigenetics and outline the available genome targeting technologies, which are used for locus-specific editing of epigenetic signals. We report early success stories and the lessons we have learned from them, and provide a guide for their application. Finally, we discuss existing limitations of the available technologies and indicate possible areas for further development.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	BioMed Central
ISSN:	1868-7075
Date of First Compliant Deposit:	11 March 2019
Date of Acceptance:	12 January 2015
Last Modified:	05 May 2023 13:08
URI:	https://orca.cardiff.ac.uk/id/eprint/118984

Citation Data

Cited 50 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item