Manganese-catalyzed N-alkylation of sulfonamides using alcohols

Reed-Berendt, Benjamin G. and Morrill, Louis C. ORCID: https://orcid.org/0000-0002-6453-7531 2019. Manganese-catalyzed N-alkylation of sulfonamides using alcohols. Journal of Organic Chemistry 84 (6) , pp. 3715-3724. 10.1021/acs.joc.9b00203

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Abstract

An efficient manganese-catalyzed N-alkylation of sulfonamides has been developed. This borrowing hydrogen approach employs a well-defined and bench-stable Mn(I) PNP pincer precatalyst, allowing benzylic and simple primary aliphatic alcohols to be employed as alkylating agents. A diverse range of aryl and alkyl sulfonamides undergoes mono-N-alkylation in excellent isolated yields (32 examples, 85% average yield).

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	American Chemical Society
ISSN:	0022-3263
Funders:	EPSRC
Date of First Compliant Deposit:	26 February 2019
Date of Acceptance:	14 February 2019
Last Modified:	07 May 2023 00:41
URI:	https://orca.cardiff.ac.uk/id/eprint/119868

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