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Manganese-catalyzed N-alkylation of sulfonamides using alcohols

Reed-Berendt, Benjamin G. and Morrill, Louis C. ORCID: 2019. Manganese-catalyzed N-alkylation of sulfonamides using alcohols. Journal of Organic Chemistry 84 (6) , pp. 3715-3724. 10.1021/acs.joc.9b00203

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An efficient manganese-catalyzed N-alkylation of sulfonamides has been developed. This borrowing hydrogen approach employs a well-defined and bench-stable Mn(I) PNP pincer precatalyst, allowing benzylic and simple primary aliphatic alcohols to be employed as alkylating agents. A diverse range of aryl and alkyl sulfonamides undergoes mono-N-alkylation in excellent isolated yields (32 examples, 85% average yield).

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Publisher: American Chemical Society
ISSN: 0022-3263
Funders: EPSRC
Date of First Compliant Deposit: 26 February 2019
Date of Acceptance: 14 February 2019
Last Modified: 07 May 2023 00:41

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