Actin-related proteins in the nucleus: life beyond chromatin remodelers

Dion, Vincent ORCID: https://orcid.org/0000-0003-4953-7637, Shimada, Kenji and Gasser, Susan M 2010. Actin-related proteins in the nucleus: life beyond chromatin remodelers. Current Opinion in Cell Biology 22 (3) , 383--391. 10.1016/j.ceb.2010.02.006

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Abstract

Since their discovery in the mid-1990s, nuclear actin-related proteins (ARPs) have gained attention for their roles as structural components of ATP-dependent chromatin-remodeling complexes. These remodelers can move nucleosomes along the DNA, evict them from chromatin, and exchange histone variants to alter chromatin states locally. Chromatin-remodeling facilitates DNA-templated processes such as transcription regulation, DNA replication, and repair. Consistent with a role for ARPs in shaping chromatin structure, recent genetic studies show that they affect developmental and cell-type specific transcriptional programming. Here, we focus on recent results that suggest a specific contribution of ARPs to long-range interactions in the nucleus, and review evidence indicating that some ARPs may act independently of chromatin-remodeling machines.

Item Type:	Article
Status:	Published
Schools:	Schools > Medicine
Publisher:	Elsevier {BV}
ISSN:	0955-0674
Last Modified:	25 Oct 2022 13:36
URI:	https://orca.cardiff.ac.uk/id/eprint/120293

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