Monocyte-macrophage activation is associated with nonalcoholic fatty liver disease and liver fibrosis in HIV monoinfection independently of the gut microbiome and bacterial translocation

Maurice, James B., Garvey, Lucy, Tsochatzis, Emmanuel A., Wiltshire, Matthew, Cooke, Graham, Guppy, Naomi, McDonald, Julie, Marchesi, Julian ORCID: https://orcid.org/0000-0002-7994-5239, Nelson, Mark, Kelleher, Peter, Goldin, Robert, Thursz, Mark and Lemoine, Maud 2019. Monocyte-macrophage activation is associated with nonalcoholic fatty liver disease and liver fibrosis in HIV monoinfection independently of the gut microbiome and bacterial translocation. AIDS 33 (5) , pp. 805-814. 10.1097/QAD.0000000000002133

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Abstract

Background: Nonalcoholic fatty liver disease (NAFLD) is common among people living with HIV. There are limited data available on the pathophysiology of NAFLD and the development of fibrosis in this population. Objectives: The aim of this study was to investigate the association of bacterial translocation, adipose tissue dysfunction, monocyte activation and gut dysbiosis in patients with HIV monoinfection and NAFLD. Methods: Cases with biopsy-proven NAFLD and HIV monoinfection were age and sexmatched to HIV-positive and HIV-negative controls. Markers of bacterial translocation [lipopolysaccharide-binding protein (LBP), bacterialDNAand lipopolysaccharide (LPS)], adipose tissue dysfunction (leptin, adiponectin) and monocyte activation (sCD14 and sCD163) were measured by ELISA. Hepatic patterns of macrophage activation were explored with immunohistochemistry. 16 s rRNA sequencing was performed with stool. Results: Thirty-three cases were included (F2 fibrosis n¼16), matched to HIV-positive (n¼29) and HIV-negative (n¼17) controls. Cases with NAFLD were more obese (BMI 31.04.4 vs. 24.12.8 kg/m2, P<0.001) and had significantly increased levels of sCD14, sCD163 and higher leptin to adiponectin ratio vs. HIV-positive controls. Cases with F2 verses

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Lippincott, Williams & Wilkins
ISSN:	0269-9370
Date of First Compliant Deposit:	8 April 2019
Date of Acceptance:	14 December 2018
Last Modified:	15 Nov 2023 08:00
URI:	https://orca.cardiff.ac.uk/id/eprint/121574

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