Silver-mediated 18F-labeling of aryl-CF3 and aryl-CHF2 with 18F-fluoride

Verhoog, Stefan, Pfeifer, Lukas, Khotavivattana, Tanatorn, Calderwood, Samuel, Collier, Thomas Lee, Wheelhouse, Katherine, Tredwell, Matthew ORCID: https://orcid.org/0000-0002-4184-5611 and Gouverneur, Veronique 2015. Silver-mediated 18F-labeling of aryl-CF3 and aryl-CHF2 with 18F-fluoride. SYNLETT 27 (01) , pp. 25-28. 10.1055/s-0035-1560592

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Abstract

We report the synthesis of [18F]arylCF3 and [18F]arylCHF2 derivatives from arylCF2Br and arylCHFCl precursors applying a silver-mediated halogen exchange with [18F]fluoride. In the absence of Ag(I)OTf, no reaction takes place at room temperature for both classes of substrates; this result demonstrates the beneficial role of silver(I) as a means to induce 18F-incorporation under very mild conditions.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Thieme Publishing / Georg Thieme Verlag
ISSN:	0936-5214
Last Modified:	04 Nov 2022 12:11
URI:	https://orca.cardiff.ac.uk/id/eprint/122207

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