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Silver-mediated 18F-labeling of aryl-CF3 and aryl-CHF2 with 18F-fluoride

Verhoog, Stefan, Pfeifer, Lukas, Khotavivattana, Tanatorn, Calderwood, Samuel, Collier, Thomas Lee, Wheelhouse, Katherine, Tredwell, Matthew ORCID: and Gouverneur, Veronique 2015. Silver-mediated 18F-labeling of aryl-CF3 and aryl-CHF2 with 18F-fluoride. SYNLETT 27 (01) , pp. 25-28. 10.1055/s-0035-1560592

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We report the synthesis of [18F]arylCF3 and [18F]arylCHF2 derivatives from arylCF2Br and arylCHFCl precursors applying a silver-mediated halogen exchange with [18F]fluoride. In the absence of Ag(I)OTf, no reaction takes place at room temperature for both classes of substrates; this result demonstrates the beneficial role of silver(I) as a means to induce 18F-incorporation under very mild conditions.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Thieme Publishing / Georg Thieme Verlag
ISSN: 0936-5214
Last Modified: 04 Nov 2022 12:11

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