Palladium-catalyzed allylic fluorination

Hollingworth, Charlotte, Hazari, Amaruka, Hopkinson, Matthew N., Tredwell, Matthew ORCID: https://orcid.org/0000-0002-4184-5611, Benedetto, Elena, Huiban, Mickael, Gee, Antony D., Brown, John M. and Gouverneur, Veronique 2011. Palladium-catalyzed allylic fluorination. Angewandte Chemie International Edition 50 (11) , pp. 2613-2617. 10.1002/anie.201007307

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Abstract

The title reaction is presented and its applicability to 18F radiolabeling is demonstrated (see scheme; TBAF=tetra‐n‐butylammonium fluoride, THF=tetrahydrofuran, dba=dibenzylideneacetone). The use of p‐nitrobenzoate as the leaving group is significant to the success of this catalytic organometallic fluorination process. A range of allylic fluorides were synthesized by this method.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Medicine
Publisher:	Wiley
ISSN:	1433-7851
Last Modified:	04 Nov 2022 12:11
URI:	https://orca.cardiff.ac.uk/id/eprint/122208

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